Univariate and multifactorial analyses showed that high expression of APOC1mRNA, lymph node metastasis, and sex were associated with OS of patients with ESCC, and APOC1 mRNA was likely an independent prognostic risk factor for OS in patients with ESCC (Table 2; Figure 4). This evidence concerns the gene APOC1 and metastatic malignant neoplasm in the lymph nodes.