CTLA4 and neoplasm: Our results showed that tumor targeting-related immune checkpoint genes such as CD274 (p = 0.0137), TGFB1 (p = 0.0175), PDCD1 (p < 0.001), CTLA4 (p < 0.001), and LAG3 (p < 0.001) were significantly associated with APOC1 (Figure 9).