APOC1 and neoplasm: Overexpression of APOC1 mRNA also significantly affected the OS of patients with ESCC at T-stage (T1 and T2) (p = 0.023) (Figure 3D), pathological stage (TNM-stage, AJCC prognostic stage) (stage I and stage II) (p = 0.039) (Figure 3E), tumor histological grade (grade 1 and grade 2) (p = 0.009) (Figure 3F), and columnar metaplasia (p = 0.027) ESCC (Figure 3G), while the effect was not significant in T-stage (T3 and T4) (p = 0.282) (Figure 3H) and pathological stage (TNM-stage, AJCC prognostic stage) (Stage III and Stage IV) (p = 0.544) (Figure 3I) as shown in the subgroup analysis.