Hesperidin, as a major dietary bioflavonoid that could cross the blood–brain barrier (Youdim et al., 2003), has been shown to exhibit antidepressant effects on CRS-and LPS-treated mice by inhibiting JNK/p38 signaling pathway (Kwatra et al., 2020, 2021). The gene discussed is MAPK8; the disease is congenital rubella syndrome.