In keeping, we showed that sCT treatment could block the augmented levels of phospho-p38/JNK in the CRS model, while the phosphorylation levels of ERK1/2 were not changed significantly (Figure 4A), possibly due to the antidepressant effects of chronic sCT largely depending on suppressing the p38 or JNK signaling pathway. This evidence concerns the gene MAPK8 and congenital rubella syndrome.