However, the ratio of p-PTEN/PTEN, p-PI3K/PI3K, p-AKT/AKT, p-mTOR/mTOR were not significantly changed between CRS-treated mice and control mice (F(2,9) = 0.7067, p > 0.05; F(2,9) = 0.6413, p > 0.05; F(2,9) = 2.146, p > 0.05; F(2,9) = 3.488, p > 0.05; Figure 4B). This evidence concerns the gene MTOR and congenital rubella syndrome.