CD4 and neoplasm: Moreover, PD-L1 blockade, CD4+ T cell depletion, or their combination not only increased the proportions of tumor-infiltrating CD44+CD69+CD8+ T cells but also elevated the proportions of central memory CD44+CD62L+CD8+ and effector memory CD44+CD62L−CD8+ T cells, compared with the control group (Figures 6(c) and 6(d)).