Neither anti-PD-L1 therapy nor depletion of CD4+ or CD8+ T cells alone changed tumor blood vessel perfusion compared to the control group, while simultaneous PD-L1 blockade and CD4+ T cell depletion significantly elevated tumor blood vessel perfusion compared to all of the other groups, indicating tumor vascular normalization (Figures 1(b) and 1(c)). The gene discussed is CD274; the disease is neoplasm.