POMC and focal segmental glomerulosclerosis: Shrivastava et al. reported a patient with steroid-dependent FSGS who developed significant remission in proteinuria when given repository porcine ACTH treatment; however, following treatment the proteinuria and anasarca re-appeared, and high titers of de novo IgG antibodies that were reactive to the porcine corticotropin were found in the patient's serum (11).