For this reason, the glucose thresholds for brain responses to insulin-induced hypoglycemia in adults (2), should be strongly considered as a guide to both the glucose thresholds for intervening (persistently <50 mg/dl [<2.8 mmol/L] in the first 48 h of life and persistently <60 mg/dl [<3.3 mmol/L] after that) and the glucose targets for treatment [>70 mg/dl (>3.9 mmol/L) for those requiring IV glucose to treat severe hypoglycemia]. This evidence concerns the gene INS and Hypoglycemia.