A genome-wide comprehensive analysis of 857 cases in a multicenter study by 50 Japanese research/medical institutions to which IgG4-RD specialists belonged showed significant correlations of IgG4-RD with HLA-DRB1 and FRGR2B genes, with the OR of the former being particularly higher than that of the latter (7). This evidence concerns the gene HLA-DRB1 and immunoglobulin G4-related sclerosing disease.