CD8A and infection: Similar to B7/N105+ CD8+ T cells, T cells targeting B40/N322 bias use the TRBV27 gene fragment, with a difference that B40/N322-specific T cell TCR repertoire exhibit a common TCRβ chain CDR3 motif TRBV27/TRBJ1-4 (20), indicating the selective recruitment of epitope-specific T cells elicited by infection.