used an unbiased screening strategy combined with the ELISpot assay and tetramer technique and identified HLA-A*02:01 restricted immunodominant epitopes A02/ORF1ab3886-3894 (KLWAQCVQL) and A02/ORF3a139-147 (LLYDANYFL) from COVID-19 patients PBMC, and observed that patients with severe disease exhibited fewer tetramer+ T cells than those with mild disease (36). This evidence concerns the gene HLA-A and COVID-19.