using the combinatorial TAME strategy analyzed two S-protein-derived epitopes- (S166-177 and S310-320) and two N-protein-derived epitopes- (N305-316 and N329-340) specific CD4+ T cell responses in COVID-19 patients with HLA-DRB1*07:01 allele, and found that the tetramer+ T cell phenotypes differed between disease severity, with more CXCR3+CCR4- Th1 cells in mildly infected individuals and impaired differentiation and formation of Th1-type CD4+ T cells in severe COVID-19 patients (32). The gene discussed is HLA-DRB1; the disease is COVID-19.