DNASE1 and Nephropathy: In addition, the blood urea nitrogen (BUN) content was examined in aging Dnase1-/-, Dnase1-/- x Siglecg-/-, Dnase1l3-/- and Dnase1l3-/- x Siglecg-/- mice, Siglecg-/- mice and wt mice to examine the consequences of kidney damage.