We further applied the LASSO regression analysis for these genes to screen the gene expression signatures of COVID-19 and IS (Figures 4B, C), and finally got five hub genes shared between two diseases (Figure 4D) ——NCR3 (natural cytotoxicity triggering receptor 3), OLR1 (oxidized low-density lipoprotein receptor 1), IL1R2 (interleukin 1 receptor type 2), IL18R1 (interleukin 18 receptor 1) and JAK2 (Janus kinase 2). This evidence concerns the gene IL18R1 and COVID-19.