Among them, CD84, FGL2, PLEK, RNASE6, ZEB2 were not detected in lung cancer tissues; C1QB, CCL4 and SPN showed low staining and weak density in the lung cancer tissue; CD14, NLRP3, SAMSN1 showed moderate staining and moderate density; MS4A6A, TMEM176B showed high staining and strong density (Supplementary Figure 5). The gene discussed is SPN; the disease is lung cancer.