SPN and lung adenocarcinoma: Compared with normal lung tissue, C1QB, NLRP3, SAMSN1, SNP, and ZEB2 were significantly downregulated in patients with lung adenocarcinoma (LUAD; Figure 5); C1QB, FGL2, MS4A6A, NLRP3, PLEK, SAMSN1, SPN, CD84 and ZEB2 were significantly downregulated in patients with lung squamous cell carcinoma (LUSC; Figure 5).