50-year-old female complaining of fatigue had an echocardiogram showing hypokinesia of the basal and medium segments of the inferior septal wall and a CT scan with mild pericardial effusion; EKG was normal; blood workup showed a slight increase of NTproBNP and troponin over 500-fold SLRR; cardiac MRI showed late enhancement of the subendocardium with hypokinesia of the same segment, as well as generalised myocardial oedema. The gene discussed is NPPB; the disease is pericardial effusion.