−Correlation in Faecalibacterium prausnitzii and Bifidobacterium bifidum with severity+Correlation in CXCL10, IL-10, TNF-α, AST, GGT CRP, LDH, NT-proBNP, and erythrocyte sedimentation rate with microbiota compositionMicrobiota distribution was associated with COVID-19 and antibiotics but not with stool SARS-CoV-2 viral replication, antiviral, corticosteroids, and pomp inhibitor use.Continuum PCA visualization of a gut microbial composition according to severity index diseasePostulated that gut microbiota was associated with the magnitude of immune response to COVID-19. This evidence concerns the gene CRP and COVID-19.