CASP7 and breast carcinoma: Panobinostat enhanced the acetylation of GRP78 (glucose-regulated protein 78) and increased endoplasmic reticulum stress via upregulation of p-eIF2α, CHOP and ATF4, and elevation of BIK, BIM, Bax and BAK expression, acceleration of the caspase-7 activity and UPR in breast cancer cells (69).