Entinostat, a cancer vaccine, and an IL15 agonist N-803 displayed a synergistic effect on tumor growth via upregulation of infiltration of CD8+ T cells, promotion of tumor inflammation-related gene expressions, enhancement of T cell responses to antigens, reduction of VISTA expression in 4T1 TNBC murine carcinoma model and MC38-CEA colon mouse model (57). This evidence concerns the gene CD8A and cancer.