Paeoniflorin could reduce cholestatic inflammation and liver fibrosis in the PBC mouse model by eliminating mtROS through the SIRT1/forkhead box O1 (FOXO1)/superoxide dismutase 2 (SOD2) signaling pathway, and thereby alleviate mitochondrial damage and inhibit NLRP3 inflammasome activation (185–187). This evidence concerns the gene FOXO1 and primary biliary cholangitis.