COXFA4L3 and carcinoma of esophagus: Moreover, the prognostic analysis showed that a high methylation level of C15orf48 was significantly associated with shorter OS, PFS, and DSS in adenoid cystic carcinoma, whereas, a low methylation level of C15orf48 was significantly associated with the poor prognosis of esophageal carcinoma (ESCA), kidney renal clear cell carcinoma (KIRC), acute myeloid leukemia, LGG, and PRAD (Figure 3D; Supplementary Figure 3B).