As an example, GAD65206-220 peptide is an immunogenic/immunodominant T cell epitope in HLA-DQ8 transgenic mice (28, 48) and in NOD mice after immunization with murine GAD65 (49) and, as such, could be considered a good pathogenic candidate for T1D in mice and humans. Here, GAD2 is linked to type 1 diabetes mellitus.