Importantly, the expression of TOX, TOX2 and members of the NR4A family was highly induced in CD8+CAR+PD-1hi1TIM3+hi tumor-infiltrating lymphocytes (TILs) by the Cl/Cn-regulated nuclear factor of activated T cells (NFAT), even in the absence of activating protein-1, which is its partner protein (41). The gene discussed is TOX2; the disease is neoplasm.