TJP1 and bacterial infectious disease with sepsis: As such, Candida worsened Bil Nep mice as indicated by mortality, liver injury (alanine transaminase), serum cytokines (TNF-α, IL-6, and IL-10), leaky gut by FITC-dextran assay, endotoxemia, serum (1➔3)-β-D-glucan (BG), and enterocyte tight junction protein (Zona occludens-1; ZO-1), but not renal injury (blood urea nitrogen and serum creatinine), and bacteremia, when compared with the control Bil Nep using only normal saline solution (NSS) gavage (Figures 1A–O).