Considering the potential protective effect of FGFR1 signaling in vascular function, we concluded that deficiency of endothelial FGFR1 by activating ROCK2 aggravated lung injury and that inhibition of ROCK2 activity was considered to be a prospective insight for prevention and treatment of ALI/ARDS. This evidence concerns the gene FGFR1 and acute respiratory distress syndrome.