In microglia of mouse models of AD, the activation of RIPK1 drives transcriptional induction of Cst7, which encodes an endosomal/lysosomal cathepsin inhibitor named Cystatin F, a biomarker for disease-associated microglia (DAM) present in spatial proximity to Aβ plaques in both postmortem human AD brain samples and in an AD mouse model (85). Here, RIPK1 is linked to Alzheimer disease.