CST7 and Alzheimer disease: In microglia of mouse models of AD, the activation of RIPK1 drives transcriptional induction of Cst7, which encodes an endosomal/lysosomal cathepsin inhibitor named Cystatin F, a biomarker for disease-associated microglia (DAM) present in spatial proximity to Aβ plaques in both postmortem human AD brain samples and in an AD mouse model (85).