RIPK3 and autoimmune lymphoproliferative syndrome: Though Mlkl−/−Fadd−/− or Ripk3−/−caspase-8−/− mice are able to fully rescue Ripk1D325A/D325A animals, there were characteristic autoimmune lymphoproliferative syndrome (ALPS) observed in the surviving mice, suggesting the role of activated RIPK1 in mediating inflammation independent of necroptosis (46, 48, 49, 60, 61).