Though Mlkl−/−Fadd−/− or Ripk3−/−caspase-8−/− mice are able to fully rescue Ripk1D325A/D325A animals, there were characteristic autoimmune lymphoproliferative syndrome (ALPS) observed in the surviving mice, suggesting the role of activated RIPK1 in mediating inflammation independent of necroptosis (46, 48, 49, 60, 61). The gene discussed is RIPK1; the disease is autoimmune lymphoproliferative syndrome.