TBK1 and amyotrophic lateral sclerosis: The genomic targets of activated RIPK1 in RIPK1 D325A MEFs, as well as in spinal cords from human ALS patients and Tbk1+/-; Tak1ΔM/+ ALS mouse model (30, 53), are highly enriched in inflammatory responses, suggesting that nuclear RIPK1 directly participates in the regulation of specific gene transcription.