Close examination of the transcriptome of ACM-treated cancer cells also revealed an increase in the expression of critical genes involved in fatty acid metabolism, including carnitine o-acyl transferase (CRAT), carnitine acylcarnitine translocase (SLC25A2O) and carnitine palmitoyl transferase I (CPT1), a critical mitochondrial enzyme involved in the β-oxidation of fatty acids (45) (Figure 3C and Supplemental Figure 5B–D). The gene discussed is CRAT; the disease is cancer.