CXCR4 and neoplasm: showed miRNAs s(miR-17, miR-129a, miR-20a, and miR-92a), thrombospondin-1(TSP-1), C-X-C chemokine receptor type 4 (CXCR4) were found in RB cells-derived Exos (77); They play a role in tumor-associated macrophages (TAMs) recruitment and proliferation (204, 205).