PTEN and metabolic dysfunction-associated steatohepatitis: using the Cre-loxP system showed hepatocyte specific knockouts of Pten, and AlbCrePten (flox/flox) mice showed huge liver hypertrophy and steatohepatitis, as well as triglyceride accumulation similar to human nonalcoholic steatohepatitis (NASH); at 78 weeks of age, all AlbCrePten (flox/flox) mice had liver adenomas, and 66% of AlbCrePten (flox/flox) mice had HCC (99).