Pten (phosphatase and tensin homolog deleted on chromosome ten) is a classical tumor suppressor gene with a mutation rate of approximately 12% in breast cancer, 1% in thyroid cancer, 2.6% in endometrial cancer, 1.6% in renal cell cancer, 5% in colon cancer, and 2% in malignant melanoma (73). This evidence concerns the gene PTEN and melanoma.