EGFR and lung cancer: established transgenic mice carrying EGFR mutations (five nucleotides encoding five amino acids were deleted, which was equivalent to the EGFRdelEN746-A750 mutation found in lung cancer patients) specifically in type II alveolar epithelial cells through its specific SP-C promoter and found that 9 of 47 newborn mice were positive for EGFR gene mutations, 3 mice of the positive type developed lung adenocarcinoma, only 1 mouse carrying lung adenocarcinoma could reproduce, and all of its offspring developed lung tumors after 7 weeks (106).