PTEN and Cachexia: Combined mutations of Kras and Pten are also common in human cancers, and the Ptf1aCre-ERTM, KrasLSL-G12D, and Ptenflox, tamoxifen-inducible triple mutant strain (KPP) may be useful as a model for pancreatic adenocarcinoma (PDA)-induced cachexia-a wasting syndrome characterized by the pronounced loss of skeletal and cardiac muscle and adipose tissues (111).