As with LN patients, where kidneys show increased levels of Psmb10 (MECL-1) and Psmb8 (LMP7) relative to kidneys from healthy individuals (11, 31), we found significantly increased expression of all 3 immunoproteasome subunits (LMP7, LMP2, and MECL-1) in kidneys derived from diseased mice treated with vehicle compared to pre-nephritic animals (Table S2). Here, PSMB10 is linked to lobular neoplasia.