Moon (77) reported an observed increase in CD4+, CD8+, and CD20+ cells in renal interstitial tissues of Type II diabetic patients and close links between CD4+ and CD20+ cells and proteinuria, indicating the underlying immunopathological correlations in DN with disorderly infiltration and the activation of T cells in renal interstitial tissues. This evidence concerns the gene CD4 and liver dysplastic nodule.