However, mutations in the N-terminal zinc finger domain, which reduces the transcriptional activation of GATA1 (36, 40), are found in patients with myeloproliferative disorders and acute megakaryoblastic leukemia (41), suggesting that GATA1-FOG1 interaction is essential for the development and maturation of megakaryocytes, the parental cells of platelets. The gene discussed is GATA1; the disease is myeloproliferative disorder.