Although the numbers were small, the immunohistochemical analysis showed that patients with high PD-L1 expression in tumor tissue may have a more significant response to PD-1 inhibitors: patients 3 and 12 who achieved CR showed higher PD-L1 scores, while patient 11 with negative PD-L1 expression did not respond to PD-1 inhibitors. The gene discussed is CD274; the disease is neoplasm.