There were similar findings by others where treatment of MDS-related AML cells or the AML cell line THP1 with different covalent LSD1 inhibitors induced upregulation of genes associated with myeloid differentiation such as GFI1, CEBPA, PU.1, IRF8, and the leukemic stem cell gene signature was repressed (19, 44). Here, IRF8 is linked to acute myeloid leukemia.