Wnt signaling is needed for both, the initiation and the maintenance of the mesenchymal phenotype of tumor cells which is mainly achieved by activating the transcription of target genes, contributing to EMT process (31, 32) and is also connected to loss of E-cadherin expression, enabling translocation of β-catenin to participate in Wnt cascade (33). The gene discussed is CDH1; the disease is neoplasm.