Interleukin 1 beta (IL1B), an important cytokine in the inflammatory response and a vital mediator of cell pyroptosis and apoptosis (8), has been actively investigated in various types of squamous carcinomas, including lung squamous cell carcinoma (9), cutaneous squamous cell carcinoma (10), and esophageal carcinoma (11), but especially oral squamous cell carcinoma (12). The gene discussed is IL1B; the disease is carcinoma of esophagus.