IL1B and head and neck squamous cell carcinoma: In this study, we: 1) identified the prognostic value and biological process of IL1B in HNSCC; 2) performed unsupervised analysis of radiomics features and constructed and validated a CECT-based radiomics model to predict IL1B expression; and 3) evaluated the feasibility of a CECT-based radiomics model for predicting the prognosis of patients with HNSCC.