To investigate the potential mechanism underlying the role of IL1B in HNSCC, functional enrichment analysis was performed on DEGs between the IL1B high- and low-expression groups using the “clusterProfile” package in R. In the BP, CC, and MF categories, the most significantly enriched GO terms relative to the IL1B expression groups were response to xenobiotic stimulus, cell-substrate junction, and signaling receptor activator activity, respectively (Figure 4A). Here, IL1B is linked to head and neck squamous cell carcinoma.