CD4 and adenocarcinoma: The antitumor effects on adenocarcinoma as well as the immunomodulation activity of active hexose correlated compound (AHCC, obtained from Lentinus edodes of Basidiomycete mush) was also evaluated clinically, it showed that AHCC treatment led to the increase of neutrophils, the ratio of CD3+/CD4+, CD4+/CD8+, CD3+/CD16+/CD56+ NK cells were also increased accordingly, while the number of lymphocytes and monocytes were reduced (131).