Another study showed that Ganoderma lucidum polysaccharide has antitumor effects on various types of advanced-stage cancer, which was achieved by stimulating host immune response, including the increased secretion of IL-2, IL-6, IFN-γ, and enhanced NK cell activity, whereas the concentration of IL-1β and TNF-α was reduced compared with baseline (128). This evidence concerns the gene TNF and cancer.