USP35 binds to ferroportin (FPN) to reduce ferroptosis triggered by erastin/RSL3, thereby promoting NSCLC proliferation. Overexpression of USP35 stabilises RRBP1, inhibits endoplasmic reticulum stress-induced apoptosis and promotes NSCLC proliferation. The gene discussed is SLC40A1; the disease is non-small cell lung carcinoma.