However, USP10 can interact with PTEN to reduce K63-linked ubiquitination of PTEN mediated by the E3 ligase TRIM25, restore PTEN activity and reduce PIP3 production, thereby inhibiting the signal transduction of mammalian target of rapamycin (mTOR) in NSCLC cells (71). This evidence concerns the gene PTEN and non-small cell lung carcinoma.