analysed 254 cases of GC (172 diffuse-type and 82 intestinal-type) using RT-PCR and situ hybridisation (FISH) and identified 26 fusion-positive cases (26/254, 10.24%), 22 of which were diffuse GCs (22/172, 12.79%), indicating that the CLDN18-ARHGAP26/6 fusion was specific to diffuse-type GCs (49). The gene discussed is CLDN18; the disease is gastric cancer.