PROX1 and central nervous system cancer: Additionally, we screened publicly available clinical data of LowerGrade Glioma (LGG) from The Cancer Genome Atlas (TCGA; www.cancergenome.nih.gov), and found that PROX1 expression levels are significantly increased in glioblastoma tumors (n=516) as compared to healthy tissue (n=698) (Figure 1A).