The first C-to-U site (chr6:31669916) resulted in a T213M mutation in CSNK2B (threonine mutated to methionine, near the C-terminal), which encodes a 215-amino acid (aa) protein as the regulatory subunit of casein kinase II (CK2), a tetrameric serine/threonine protein kinase that is upregulated in various cancers (34). This evidence concerns the gene AKT1 and cancer.