In conclusion, the present study demonstrated that the active components of SNL for the treatment of colon cancer include quercetin, apigenin, kaempferol, and luteolin, and the effective targets include AURKB, PIK3R1, CDK1, CDK2, GSK3B, CCNA2, CCND1, CCNB1, CASP3, CCNA2, and STAT1. Here, CCND1 is linked to malignant colon neoplasm.