Figures 3C and S6a show that the most enriched biological processes were peptidyl-proline hydroxylation, extracellular matrix organization, angiogenesis, response to hypoxia, cellular response to hypoxia, negative regulation of smooth muscle cell migration, maternal behavior, response to peptide hormone, and peptidyl-tyrosine phosphorylation. Figures 3D and S6B show that the most enriched KEGG pathways were HIF-1 signaling, cholesterol metabolism, carbon metabolism in cancer, p53 signaling, axon guidance, circadian rhythm, MAPK signaling, fructose and mannose metabolism, and TGF-β signaling. The gene discussed is TGFB1; the disease is cancer.