And plasma samples validated that the significant differences existed in the expression levels of CCL20, and SLC7A2 between HCC and normal tissues, that is, CCL20 was highly expressed in most HCC plasma samples while the expression of SLC7A2 was significantly higher in normal plasma samples than in virus-related HCC plasma samples (Figure 10A). This evidence concerns the gene SLC7A2 and hepatocellular carcinoma.