Regarding what is known about the role played by the non-canonical Wnt/Ca2+ pathway in colon cancer patients, accumulating evidence has shown that the prototypal non-canonical Wnt5a ligand-mediated actions, along with an increase in Ror1/Ror2 non-canonical co-receptors expression have been found to be associated with an aggressive phenotype in colon cancer patients. The gene discussed is ROR2; the disease is colonic neoplasm.