Similarly, in breast cancer, miR-424 suppresses the cell invasion and stem cell traits under hyperglycemic conditions through the attenuated inhibitory function of miR-424 on CDC42, leading to the activation of PR/SET domain 14 (PRDM14), which is a repressor of pluripotent transcription factors (101, 102). This evidence concerns the gene PRDM14 and breast carcinoma.