RAC1 and neoplasm: Another in vitro study showed that miR-141 exerts the ability to inhibit tumor growth and metastasis properties of PCSs via targeting the Rho GTPase signaling-associated components, including CDC42, CDC42EP3, RAC1 (ras-related C3 botulinum toxin substrate 1), and ARPC5 (actin-related protein 2/3 complex subunit) (87).