Homozygous or compound heterozygous PVs in FANCC and ERCC5 are known to be linked to autosomal recessive disorders, Fanconi anemia complementation group C (MIM: 227645) and Xeroderma pigmentosum complementation group G (MIM: 278780), respectively, known to exhibit increased risk to cancer. The gene discussed is FANCC; the disease is Fanconi anemia.