Our investigation of potentially deleterious variants in 468 genes that play a direct or associated role in various DNA repair pathways in the FC population exhibiting genetic drift identified LoF and potentially deleterious missense variants as candidates for OC predisposition in ERCC5, EXO1, FANCC, NEIL1 or NTHL1. Genotyping analyses of independently ascertained FC cancer study groups identified multiple carriers with OC harbouring the same variant, which is likely due to common ancestors within the FC population of Quebec (33–35). The gene discussed is ERCC5; the disease is cancer.