NTHL1 and cancer: Noteworthy, the frequency of all LoF rare (MAF ≤0.005) variants in these genes in the cancer-free gnomAD v2.1.1 controls as follows: 112/1,563 (0.07) in ERCC5; 105/1,207 (0.09) in EXO1; 87/943 (0.09) in FANCC; 85/811 (0.1) in NEIL1 and 47/629 (0.07) in NTHL1. Collectively, candidate variants we identified in cancer cases are comprised of three nonsense, four frameshift, three alternative splicing and nine missense variants.