Noteworthy, the frequency of all LoF rare (MAF ≤0.005) variants in these genes in the cancer-free gnomAD v2.1.1 controls as follows: 112/1,563 (0.07) in ERCC5; 105/1,207 (0.09) in EXO1; 87/943 (0.09) in FANCC; 85/811 (0.1) in NEIL1 and 47/629 (0.07) in NTHL1. Collectively, candidate variants we identified in cancer cases are comprised of three nonsense, four frameshift, three alternative splicing and nine missense variants. Here, EXO1 is linked to cancer.