FANCC and cancer: In these study groups, we identified: one of the 9 MIX familial OC cases (11.1%) harbouring a NTHL1 variant; 17 of 516 AUS OC cases (3.3%) harbouring 11 variants in NTHL1 (n=6), NEIL1 (n=3), ERCC5 (n=1) and EXO1 (n=1); 12 of 412 Pan-Cancer – TCGA OC cases (2.9%) harbouring 10 variants in NEIL1 (n=4), EXO1 (n=2), FANCC (n=2), NTHL1 (n=1) and ERCC5 (n=1) (Table S6 and Figure 4).