Non-NF2 variants of meningiomas are more complex and include Hedgehog signaling pathway variants (SMO, SUFU, PRKAR1A, PTCH1/2, etc.), phosphatidylinositol 3-kinase (PI3K) signaling pathway variants (PTEN, AKT1, PIK3CA, PIK3R1, etc.), chromosome remodeling complex variants (SMARCB1, SMARCE1, ARID1A, PBRM1, etc.)and other gene variants (KLF4, BAP1, POLR2A, DMD, etc.)(43). This evidence concerns the gene PIK3CA and meningioma.