Another part is related to the degree of tumor malignancy, such as the deletion of histone H3 K27me3 expression is closely associated with meningioma recurrence (50–52), TERT promoter mutation and CDKN2A/B pure deletion are molecular biological markers of CNS WHO grade 3 meningioma (53, 54). This evidence concerns the gene CDKN2A and meningioma.