Another part is related to the degree of tumor malignancy, such as the deletion of histone H3 K27me3 expression is closely associated with meningioma recurrence (50–52), TERT promoter mutation and CDKN2A/B pure deletion are molecular biological markers of CNS WHO grade 3 meningioma (53, 54). The gene discussed is CDKN2A; the disease is neoplasm.