Non-NF2 variants of meningiomas are more complex and include Hedgehog signaling pathway variants (SMO, SUFU, PRKAR1A, PTCH1/2, etc.), phosphatidylinositol 3-kinase (PI3K) signaling pathway variants (PTEN, AKT1, PIK3CA, PIK3R1, etc.), chromosome remodeling complex variants (SMARCB1, SMARCE1, ARID1A, PBRM1, etc.)and other gene variants (KLF4, BAP1, POLR2A, DMD, etc.)(43). The gene discussed is SUFU; the disease is meningioma.