PBRM1 and meningioma: Non-NF2 variants of meningiomas are more complex and include Hedgehog signaling pathway variants (SMO, SUFU, PRKAR1A, PTCH1/2, etc.), phosphatidylinositol 3-kinase (PI3K) signaling pathway variants (PTEN, AKT1, PIK3CA, PIK3R1, etc.), chromosome remodeling complex variants (SMARCB1, SMARCE1, ARID1A, PBRM1, etc.)and other gene variants (KLF4, BAP1, POLR2A, DMD, etc.)(43).