We have also reported that, in the Otsuka Long Evans Tokushima Fatty rat (animal model of obesity) and in the SHR/NDmcr-cp animal model of metabolic syndrome, treatment of an SGLT2 inhibitor normalized the dipping pattern of blood pressure in addition to its antihypertensive effects (12, 13). The gene discussed is SLC5A2; the disease is obesity due to melanocortin 4 receptor deficiency.