It has already been proven that the levels of some proinflammatory cytokines, such as interleukin (IL)-1a, IL-6 IL-8, IL-17a, TNF-alpha, and IFN-c, were higher in the aqueous humor of eyes with bullous keratopathy and a low density of ECs (16, 17). Here, IL1A is linked to vesiculobullous skin disease.