As would be expected, SARS-CoV-2 infection upregulated mediators of viral antigen presentation including HLA haplotypes HLA-B, HLA-I, and HLA-DRB. This observation is important as HLA-B and HLA-DRB have both been reported to influence COVID-19 disease severity (20, 21) in association with preexisting medical comorbidities such as cardiovascular disease (22). Here, HLA-DRB1 is linked to cardiovascular disorder.