Obesity and impaired fasting glucose (IGF) were more frequently diagnosed in a subgroup with SHBG below 26.1 nmol/L (59.1% vs. 18.6%; p < 0.001 and 17.2% vs. 6.7%; p < 0.001, respectively). The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.