The role of SHBG in type 2 diabetes development is supported by experimental studies performed with the insulin-resistant human trophoblast cells (HTR8-SVneo cell line) characterized by low expression of SHBG, GLUT-3 and GLUT-4 (glucose transporters type 3 and 4) as well as high expression of GLUT-1. This evidence concerns the gene SHBG and type 2 diabetes mellitus.