Different from the aforementioned studies that used candidate gene approaches, Moschny et al. (2020a) identified 5 genes (RNF175, RNF213, TBC1D14, TMC5, and WSCD1) and 3 non-coding RNAs (AC018685.2, AC098617.1, and CLCN3P1), differentially methylated, using a genome-wide approach in samples of TRD patients undergoing ECT. Here, TMC5 is linked to treatment resistant depression.