F8 and hyperinsulinemic hypoglycemia, familial, 4: Although the FVIII is mainly synthesized in liver sinusoidal endothelial cells (LSECs) under physiological conditions (Shahani et al., 2014; Hayakawa et al., 2021), many studies demonstrated that the ectopic expression of FVIII in hepatocytes was efficient and the FVIII deficiency in HA mice and HA patients were rescued (Bunting et al., 2018; Chen et al., 2019; Zhang et al., 2019).