Of the 11 genes screened using the RF classifier, KLF12 (Natarajan et al., 2022), IL23A (Khader et al., 2011), NELL2 (Yang et al., 2015), OSBPL10 (Li et al., 2022), C1QC (Cai et al., 2014), and ID3 (Han et al., 2021) have been identified as candidate biomarkers of TB in previous studies. The gene discussed is KLF12; the disease is tuberculosis.