The nomogram has been recognized as a reliable tool for quantifying disease risk based on multivariate modeling procedures (Luo et al., 2015), and the nomogram constructed by target genes such as CCND2, WT1, E2F2, and IRF1 has been demonstrated to be robust; consequently, CCND2, WT1, E2F2, and IRF1 may be reliable OSA targets. The gene discussed is E2F2; the disease is obstructive sleep apnea syndrome.