In conclusion, we hypothesize that lncRNA STRBP may compete with miRNA (hsa-miR-1297, hsa-miR-17-5p, hsa-miR-20b-5p, hsa-miR-125b-5p, hsa-miR-301b-3p, and hsa-miR-212-3p) for binding, thereby regulating the target genes of CCND2, WT1, E2F2, and IRF1, affecting the occurrence and development of OSA; however, the specific pathogenesis still warrants further investigation. The gene discussed is E2F2; the disease is obstructive sleep apnea syndrome.